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cthia
Fleet Admiral
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Joined: Thu Jan 23, 2014 1:10 pm
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The E wrote:cthia wrote:
Perhaps you are on to something important. Yet do not fail to consider the fact that the virus is believed to have been hidden in the Kitum cave in Africa and its first documented victim was a Frenchman, Charles Monet, who ended up in Africa for whatever reason. He was not a poor African villager. It seems to me that if the virus was health, or malnutrition dependent, it would have long been contracted by said malnourished Africans, and not originally contracted by a primarily healthy Frenchman. The Frenchman had been in the Kitum cave and had possibly been cut by a rock, it is believed.
You are mixing facts here. The Kitum cave harbors a strand of the Marburg virus, which isn't Ebola. It is a hemorrhagic fever, yes, but it is far less virulent than Ebola, with under 400 known cases in the 57 years after it was first isolated (incidentally, it was first found in the german city of Marburg). Monet wasn't the first person to contract the disease (he died in 1980); just the first known person to die of that specific strand of the virus.
No, I am not mixing the three. Perhaps I should have stated that Monet was infected by Marburg, however, I have pleaded for many to read the book for themselves. Marburg, though not considered to be Ebola, is in the Ebola "filovirus" family and yes it is considered to be the mildest of the "filovirus" sisters. But in the filovirus family with Ebola. BSL-4!HOT ZONE wrote:
Marburg is one of a family of viruses known as the filoviruses. Marburg was the first filovirus to be discovered. The word filovirus is Latin and means "thread virus". The filoviruses look alike, as if they are sisters, and they resemble no other virus on earth.
-snip-
Not long after Charles Monet died, it was established that the family of filoviruses comprised Marburg along with two types of virus called Ebola. The Ebolas were named Ebola Zaire and Ebola Sudan. Marburg was the mildest of the three filovirus sisters. The worst of them was Ebola Zaire.
The kill rate in humans infected with Ebola Zaire is nine out of ten. Ninety percent of the people who come down with Ebola Zaire die of it. Ebola Zaire is a slate wiper in humans. Marburg virus (the gentle sister) affects humans somewhat like nuclear radiation, damaging virtually all of the tissues in their bodies. It attacks with particular ferocity the internal organs, connective tissue, intestines, and skin. In Germany, all the survivors lost their hair-they went bald or partly bald. Their hair died at the roots and fell out in clumps, as if they had received radiation burns. Hemorrhage occurred from all orifices of the body. I have seen a photograph of one of the men who died of Marburg, taken in the hours before his death. He is lying in bed without any clothing on his upper body. His face is expressionless. His chest, arms, and face are speckled with blotches and bruises, and droplets of blood stand on his nipples.
During the survivors' recovery period, the skin peeled off their faces, hands, feet, and genitals. Some of the men suffered from blown up, semirotten testicles. One of the worst cases of this appeared in a morgue attendant who had handled Marburg-infected bodies. The virus also lingered in the fluid inside the eyeballs of some victims for many months.
No one knows why Marburg has a special affinity for the testicles and the eyes. One man infected his wife with Marburg through sexual intercourse.
Doctors noticed that the Marburg agent had a strange effect on the brain. "Most of the patients showed a sul en, slight aggressive, or negativistic behavior," according to the book. "Two patients (had) a feeling as if they were lying on crumbs." One patient became psychotic, apparently as a result of brain damage. The patient named Hans O.-V.
showed no signs of mental derangement, and his fever cooled, and he seemed to be stabilizing, but then suddenly, without warning, he had an acute fall in blood pressure-he was crashing-and he died. They performed an autopsy on him, and when they opened his skull, they found a massive, fatal hemorrhage at the center of the brain. He had bled out into his brain.
International health authorities were urgently concerned to find the exact source of the monkeys, in order to pin down where in nature the Marburg virus lived. It seemed pretty clear that the Marburg virus did not natural y circulate in monkeys, because it killed them so fast it could not successfully establish itself in them as a useful host.
Therefore, Marburg lived in some other kin of host-an insect? a rat? a spider? a reptile? Where, exactly, had the monkeys been trapped? That place would be the hiding place of the virus. Soon after the outbreak in Germany, a team of investigators under the auspices of the World Health Organization flew to Uganda. The team couldn't discover the exact source of the virus.
There the mystery lingered for many years. Then, in 1982, an English veterinarian came forward with new eyewitness information about the Marburg monkeys. I wil cal this man Mr. Jones (today, he prefers to remain anonymous). During the summer of 1967, when the virus erupted in Germany, Mr. Jones was working at a temporary job inspecting monkeys at the export facility in Entebbe from which the sick Marburg monkeys had been shipped, while regular veterinary inspector was on leave. This monkey house, which was run by a rich monkey trader ("a sort of lovable rogue," according to Mr. Jones) was exporting about thirteen thousand monkeys a year to Europe. This was a very large number of monkeys, and it generated big money. The infected shipment was loaded onto an overnight flight to London, and from there it was flown to Germany-where the virus broke out of the monkeys and "attempted" to establish itself in the human population.
After making a number of telephone cal s, I final y located Mr. Jones in a town in England, where today he is working as a veterinary consultant. He said to me: "Al that animals got, before they were shipped off, was a visual inspection."
"By whom?" I asked.
"By me," he said. "I inspected them to see that they appeared normal. On occasion, with some of these shipments, one or two animals were injured or had skin leisons." His method was to pick out the sick-looking ones, which were removed from the shipment and presumably kil ed before the remaining healthy-looking animals were loaded onto the plane. When, a few weeks later, the monkeys started the outbreak in Germany, Mr. Jones felt terrible. "I was appal ed, because I had signed the export certificate," he said to me. "I feel now that I have the deaths of these people on my hands. But that feeling suggests I could have done something about it. There was no way I could have known." He is right about that: the virus was then unknown to science, and as few as two or three not-visibly-sick animals could have started the outbreak.
One concludes that the man should not be blamed for anything.
The story becomes more disturbing. He went on: "The sick ones were being kil ed, or so I thought." But later he learned that they weren't being kil ed. The boss of the company was having the sick monkeys put in boxes and shipped out to a smal island in Lake Victoria, where they were released. With so many sick monkeys running around it, the island could have become a focus for monkey viruses. It could have been a hot island, an isle of plagues. "Then, if this guy was a bit short of monkeys, he went out to the island and caught a few, unknown to me." Mr. Jones thinks it is possible that the Marburg agent had established itself on the hot island, and was circulating among the monkeys there, an that some of the monkeys which ended up in Germany had actually come from that island. But when the WHO team came later to investigate, "I was told by my boss to say nothing unless asked." As it turned out, no one asked Mr. Jones any questions-he says he never met the WHO team. The fact that the team apparently never spoke with him, the monkey inspector, "was bad epidemiology but good politics," he remarked to me. If it had been revealed that the monkey trader was shipped off suspect monkeys collected on a suspect island, he could have been put out of business, and Uganda would have lost a source of valuable foreign cash.
Shortly after the Marburg outbreak, Mr. Jones recal ed a fact that began to seem important to him. Between 1962 and 1965 he had been stationed in eastern Uganda, on the slopes of Mount Elgon, inspecting cattle for disease. At some time during that period, local chiefs told him that the people who lived on the north side of the volcano, along the Greek River, were suffering from a disease that caused bleeding, death, and "a particular skin rash"-and that monkeys in the area were dying of a similar disease. Mr. Jones did not pursue the rumors, and was never able to confirm the nature of the disease. But it seems possible that in the years preceding the outbreak of Marburg virus in Germany, a hidden outbreak of the virus occurred on the slopes of Mount Elgon.
MR. JONES'S PERSONAL VISION of the Marburg outbreak reminds me of a flashlight pointed down a dark hole. It gives a narrow but startling view of the larger phenomenon of the origin and spread of tropical viruses. He told me that some of the Marburg monkeys were trapped in a group of islands in Lake Victoria known as the Sese Islands.
The Senses are a low-lying forested archipelago in the northwestern part of Lake Victoria, an easy boat ride from Entebbe. The isle of plagues may have been situated among the Senses or near them. Mr. Jones does not recal the name of the hot island. He says it is close to Entebbe. At any rate, Mr. Jones's then-boss, the Entebbe monkey trader, had arranged a deal with vil agers in the Sese Islands to buy monkeys from them. They regarded the monkeys as pests and were happy to get rid of them, especial y for money.
So the trader was obtaining wild monkeys from Sese Islands, and if the animals proved to be sick, he was releasing them on another island somewhere near Entebbe. And some monkeys from the isle of plagues seemed to be ending up in Europe.
In papyrus reeds and desolate flatlands on the western shore of Lake Victoria facing the Sese Islands, there is a fishing vil age cal ed Kasensero. You can see the Sese Islands from the vil age. Kasensero was one of the first places in the world where AIDS appeared. Epidemiologists have since discovered that the northwestern shore of Lake Victoria was one of the initial epicenters of AIDS. It is general y believed that AIDS
came original y from African primates, from monkeys and apes, and that it somehow jumped out of these animals into the human race. It is thought that the virus went through a series of very rapid mutations at the time of its jump from primates to humans, which enabled it to establish itself successfully in people. In the years since AIDS virus emerged, the vil age of Kasensero has been devastated. The virus has kil ed a large portion of the inhabitants. It is said that other vil ages along the shores of Lake Victoria have been essential y wiped off the map.
The vil agers of Kasensero are fishmen who were, and are, famous as smugglers. In their wooden boats and motorized canoes they ferried il egal goods back and forth across the lake, using the Sese Islands as hiding places. One can guess that if a monkey trader were moving monkeys around Lake Victoria, he might cal on the Kasensero smugglers or on their neighbors.
One general theory for the origin of AIDS goes that, during the late nineteen-sixties, a new and lucrative business grew up in Africa, the export of primates to industrialized countries for use in medical research. Uganda was one of the biggest sources of these animals. As the monkey trade was established throughout central Africa, the native workers in the system, the monkey trappers and handlers, were exposed to large numbers of wide monkeys, some of which were carrying unusual viruses.
These animals, in turn, were being jammed together in cages, exposed to one another, passing viruses back and forth. furthermore, different species of monkeys were mixed together. It was a perfect setup for an outbreak of a virus that could jump species. It was also a natural laboratory for rapid virus evolution, and possibly it led to the creation of HIV. Did HIV crash into the human race as a result of the monkey trade? Did AIDS come from an island in Lake Victoria? A hot island? Who knows. When you begin probing into the origins of AIDS and Marburg, the light fails and things go dark, but you sense hidden connections. Both viruses seem part of a pattern.
WHEN HE LEARNED what Marburg virus does to human being, Dr. David Silverstein persuaded the Kenyan health authorities to shut down Nairobi Hospital.
Perhaps not technically, but to me all three are the same. I wouldn't want to tangle with Ebola, or its little sister. It was the first documented case, in Africa. It does explain in the book its German origin, hence the German name and the first German person, Klaus F. infected. Edit: Included more passage from "The Hot Zone." Last edited by cthia on Tue Aug 12, 2014 9:47 am, edited 1 time in total.
Son, your mother says I have to hang you. Personally I don't think this is a capital offense. But if I don't hang you, she's gonna hang me and frankly, I'm not the one in trouble. —cthia's father. Incident in ? Axiom of Common Sense
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