The most common cause for bullet breakup is that the jacket is to thin many of the light weight .22 varmint bullets have very thin jackets for explosive terminal performance but do not do well above about 3400 fops even with a relatively slow twist like 1:14.
In general the faster the muzzle velocity the slower the required twist for the same projectile.
Most 22-250s are 1:14 and most non MSR .223s are 1:12 they both shoot the same basic group of projectiles from any given manufacturer which need a certain a RPM to stabilize. At the same velocity a 1:12 will spin about 16% faster. In this example the 22-250 normally shoots about 3800 fops while the 223 shoots about 3000 with a 55 grain bullet a difference of a little over 20% which means the actual RPM on the bullet is about the same.
Under stabilized bullets will keyhole or tumble through the air and make really strange holes in your target.
Within reason, You cannot really over stabilize but high twist bbls wear faster, slow the bullet more and can cause core / jacket separation. They make .223 rem / 5.56 NATO bbls from 1:14 all the way to 1:7 twist without even having to call the custom shop
